The molecular mechanisms of gap junction remodeling

Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction.

Lateralization of the ventricular gap junction protein connexin 43 (Cx43) occurs in epicardial border zone myocytes following myocardial infarction (MI) and is arrhythmogenic. Alterations in Cx43 protein partners have been hypothesized to play a role in lateralization although mechanisms by which this occurs are unknown. To examine potential mechanisms we did nuclear magnetic resonance, yeast 2...

Mechanisms of Postinfarction Electrophysiological Abnormality: Sympathetic Neural Remodeling, Electrical Remodeling and Gap Junction Remodeling

Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias.

a,c,d , b c,d * Jeffrey E. Saffitz , Richard B. Schuessler , Kathryn A. Yamada Department of Pathology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Medicine, Washington University School of Medicine, 660 Sout...

Molecular mechanisms of myocardial remodeling.

"Remodeling" implies changes that result in rearrangement of normally existing structures. This review focuses only on permanent modifications in relation to clinical dysfunction in cardiac remodeling (CR) secondary to myocardial infarction (MI) and/or arterial hypertension and includes a special section on the senescent heart, since CR is mainly a disease of the elderly. From a biological poin...

Gap junction remodeling in skin repair following wounding and disease.

In the present review, we provide an overview of connexin expression during skin development and remodeling in wound healing, and reflect on how loss- or gain-of-function connexin mutations may change cellular phenotypes and lead to diseases of the skin. We also consider the therapeutic value of targeting connexins in wound healing.